St. John's Episcopal Church, on Madison Square, was designed by Calvin Otis, an architect from Buffalo, New York. Built in 1853, the church displays the pointed arches, buttresses and hammerbeam trusses characteristic of its Gothic-Revival style. Its roof has oxidized to the beautiful verdigris seen in "Copper Roof". The church is known for its elegant stained-glass windows, exquisitely detailed reredos, and traditional (1928 Book of Common Prayer) liturgy.

The First African Baptist Church in Savannah, Georgia, is the oldest black church in North America. First organized in December 1777, the present building was erected in 1859, with members of the congregation doing the work themselves. The first building constructed of brick in the State of Georgia and owned by blacks, it was for many years known as the "Brick Church." The steeple in "Toward Heaven" replaced a grander one that was blown off during a hurricane in 1892.

Christ Church (Episcopal) was founded in 1733 with the establishment of the Georgia colony and is Georgia's oldest congregation. General James Oglethorpe specified the location for the church in his distinctive plan for Savannah, but the present Greek-Revival style building, located on Johnson Square, was not erected until much later. In 1895, a fire damaged the interior of the church, and its current interior is largely the result of the renovation that followed. The Italian marble baptismal font in "Spirit of Grace" is the twin of one at the Cathedral in Cologne, Germany.

Independent Presbyterian Church has been called, “Savannah’s most notable building". The current building, with its remarkable architectural detail, built after a devastating fire in 1889 destroyed the previous structure, is a replica of its 1819 predecessor. Supervising the reconstruction of the church was Boston architect, William Preston Gibbons.

Congregation Mickve Israel was founded by mostly Portuguese Jews and two German Jewish families who arrived in Savannah on July 11, 1733. In 1790 the congregation was granted a Charter from the State of Georgia. It is the third oldest Jewish congregation in the United States. The only neo-Gothic synagogue in the United States, the current building, which stands on Monterey Square, was dedicated in 1878.